Getting Things Backwards to Prevent Primer Dimers

Getting a Few Things Right and Many Things Wrong

Planar Cell Polarity: The Importance of Getting It Backwards

The core and Fat-Dachsous signaling systems locally align planar cell polarities in Drosophila epithelia. Three recent papers address how coupling between these systems can be altered and reversed by the products of the gene prickle.

First things first: getting primary care right.

G IVEN THE BROAD AGENDA, HIGH EXPECtations , increasing patient complexity, growing evidence base, intensifying threats to provider work dissatisfaction , and the worsening workforce shortage of primary care physicians, there is an urgent need to fix the problems of primary care. Primary care has been marginalized, and our own professional societies have encountered numerous obstacles in advoca...

Things Are Getting Hairy: Enterobacteria Bacteriophage vB_PcaM_CBB

Enterobacteria phage vB_PcaM_CBB is a "jumbo" phage belonging to the family Myoviridae. It possesses highly atypical whisker-like structures along the length of its contractile tail. It has a broad host range with the capability of infecting species of the genera Erwinia, Pectobacterium, and Cronobacter. With a genome of 355,922 bp, excluding a predicted terminal repeat of 22,456 bp, phage CBB ...

Getting it right when things go wrong.